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This page presents data from the FDA Adverse Event Reporting System (FAERS) and the FDA-approved drug label. A report submitted to FAERS does not prove a drug caused the reported event. Always consult a healthcare provider about medications.

Acid Reducer (esomeprazole magnesium)

Last updated: June 18, 2026
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Acid Reducer is the brand name for esomeprazole magnesium. According to the FDA-approved label, treats frequent heartburn (occurs 2 or more days a week) not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect. FAERS contains 230,599 submissions naming this drug from 2002 through 2026; the top three reactions cited are chronic kidney disease, acute kidney injury, and renal failure.

Most-Reported Reactions

Counts of the reactions most often cited in FAERS submissions that named Acid Reducer. Inclusion here does not establish causation - submitters describe what was observed, not what was confirmed. One submission can list several reactions, so the totals exceed the report count.

CHRONIC KIDNEY DISEASE 35,571 (15.4%) ACUTE KIDNEY INJURY 20,372 (8.8%) RENAL FAILURE 16,252 (7.0%) DRUG INEFFECTIVE 14,187 (6.2%) NAUSEA 13,253 (5.7%) GASTROOESOPHAGEAL REFLUX DISEASE 11,947 (5.2%) DRUG DOSE OMISSION 11,122 (4.8%) DIARRHOEA 10,976 (4.8%) PAIN 10,569 (4.6%) END STAGE RENAL DISEASE 10,297 (4.5%) MALAISE 9,854 (4.3%) FATIGUE 9,739 (4.2%) RENAL INJURY 9,527 (4.1%) HEADACHE 9,397 (4.1%) OFF LABEL USE 9,358 (4.1%)

Patient Demographics

Patient sex and age across the FAERS submissions that named Acid Reducer. Percentages here are computed only from submissions where these fields were filled in - many leave them blank.

By Sex

Female Male Unknown

By Age Group

0-17 18-44 45-64 65+

Severity Outcomes

Severity flags recorded across the 230,599 FAERS submissions that named Acid Reducer. Each bar shows the count of those reports carrying that flag. A single case can carry more than one (a hospitalization that became life-threatening, for example), so these bars are independent rates - they don't sum to 100%. Inclusion of a case under any flag does not establish that the drug caused the outcome.

DEATH 19,254 (8.3%) HOSPITALIZATION 71,083 (30.8%) LIFE-THREATENING 8,786 (3.8%) DISABLING 6,488 (2.8%)

Submissions Per Quarter

Quarterly count of FAERS submissions that named Acid Reducer. Ups and downs on this chart can track prescribing volume, news cycles, or shifts in how reports get filed, rather than the drug becoming safer or more dangerous.

2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026

From the FDA-Approved Label

Excerpts from the official FDA-approved prescribing information for Acid Reducer. This is the authoritative source on indications, warnings, and known adverse reactions.

Indications

treats frequent heartburn (occurs 2 or more days a week) not intended for immediate relief of heartburn; this drug may take 1 to 4 days for full effect

Warnings

Allergy alert : Do not use if you are allergic to esomeprazole. Esomeprazole may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If an allergic reaction occurs, stop use and seek medical help right away.

FDA label effective date: 2026-01-21

Disclaimer

AdverseEvent.ai is not affiliated with the FDA. Adverse-event counts come from the FDA Adverse Event Reporting System (FAERS). Drug labels come from the FDA drug label dataset. A report submitted to FAERS does not prove a drug caused the reported event — always consult a healthcare provider about medications. This site is for informational purposes only and is not medical advice.